Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GPR6 | P46095 | 5/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HBB | P68871 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2221956 | 0.89 | MAPT (0.52) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2222782 | 0.87 | MAPT (0.51) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2221823 | 0.85 | MAPT (0.53) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2223056 | 0.84 | L3MBTL1 (0.58) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL2223177 | 0.84 | MAPT (0.52) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2221685 | 0.82 | MAPT (0.50) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL2221555 | 0.82 | MAPT (0.49) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2222904 | 0.81 | MAPT (0.55) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2221551 | 0.81 | MAPT (0.66) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2221569 | 0.81 | MAPT (0.54) | MAPTKDM4EPOLBNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088201-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-07-21 | — | — | WO | disclosed |