SCHEMBL22229673

SCHEMBL22229673

Oc1c(-c2ccccc2-c2ccc3ccccc3c2)cc2c(c1-c1c(O)c(-c3ccccc3-c3ccc4ccccc4c3)cc3c1CCCC3)CCCC2

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
HDAC4 P56524 1/20 0.49
HDAC2 Q92769 1/20 0.49
HDAC8 Q9BY41 1/20 0.49
NQO1 P15559 2/20 0.39
ESR2 Q92731 2/20 0.38
GSTP1 P09211 1/20 0.38
ESR1 P03372 1/20 0.38
ALOX5 P09917 1/20 0.37
AGTR2 P50052 1/20 0.36
HSD17B1 P14061 1/20 0.36
HSD17B2 P37059 1/20 0.36
SLC6A2 P23975 4/20 0.36
SLC6A3 Q01959 3/20 0.36
SLC6A4 P31645 1/20 0.36
ERN1 O75460 1/20 0.34
MIF P14174 1/20 0.34
DRD1 P21728 1/20 0.34
HTR2A P28223 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22229672 0.78 GPR84 (0.57) MEN1KMT2AHDAC4HDAC2HDAC8
SCHEMBL16772616 0.76 MEN1 (0.64) MEN1KMT2AHDAC4HDAC2HDAC8
SCHEMBL22229757 0.76 SLC6A2 (0.36) MEN1KMT2AHDAC4HDAC2HDAC8
SCHEMBL28689878 0.73 GPR84 (0.40) NQO1ESR2GSTP1ESR1ALOX5
SCHEMBL598168 0.72 HDAC4 (0.72) HDAC4HDAC2HDAC8ESR2GSTP1
SCHEMBL30335758 0.72 HDAC4 (0.72) HDAC4HDAC2HDAC8ESR2GSTP1
SCHEMBL28508645 0.70 GSTP1 (0.70) HDAC4HDAC2HDAC8ESR2GSTP1
SCHEMBL30491158 0.70 GSTP1 (0.70) HDAC4HDAC2HDAC8ESR2GSTP1
SCHEMBL18162771 0.69 HDAC4 (0.58) HDAC4HDAC2HDAC8ESR2GSTP1
SCHEMBL19211556 0.68 HDAC4 (0.66) HDAC4HDAC2HDAC8ESR2GSTP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11664093-B2 Extrapolative prediction of enantioselectivity enabled by computer-driven workflow, new molecular representations and machine learning THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2023-05-30 US disclosed
US-11664093-B2 Extrapolative prediction of enantioselectivity enabled by computer-driven workflow, new molecular representations and machine learning THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2023-05-30 US disclosed
US-11664093-B2 Extrapolative prediction of enantioselectivity enabled by computer-driven workflow, new molecular representations and machine learning THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2023-05-30 US disclosed
US-20200234798-A1 EXTRAPOLATIVE PREDICTION OF ENANTIOSELECTIVITY ENABLED BY COMPUTER-DRIVEN WORKFLOW, NEW MOLECULAR REPRESENTATIONS AND MACHINE LEARNING THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 2020-07-23 US disclosed
US-20200234798-A1 EXTRAPOLATIVE PREDICTION OF ENANTIOSELECTIVITY ENABLED BY COMPUTER-DRIVEN WORKFLOW, NEW MOLECULAR REPRESENTATIONS AND MACHINE LEARNING THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 2020-07-23 US disclosed