SCHEMBL22229688

SCHEMBL22229688

O=P1(O)Oc2c(-c3c(Cl)cc(Cl)cc3Cl)cc3c(c2-c2c4c(cc(-c5c(Cl)cc(Cl)cc5Cl)c2O1)CCCC4)CCCC3

nearest known ligand 0.38

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 8/20 0.38
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
KDM4E B2RXH2 1/20 0.33
RECQL P46063 1/20 0.32
NOTUM Q6P988 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17436482 0.85 GPR84 (0.54) GPR84MEN1KMT2AKDM4ERECQL
SCHEMBL13868304 0.81 GPR84 (0.54) GPR84MEN1KMT2AKDM4ERECQL
SCHEMBL22229709 0.78 MEN1 (0.49) GPR84MEN1KMT2AKDM4ERECQL
SCHEMBL3921033 0.78 MEN1 (0.37) GPR84MEN1KMT2AKDM4ERECQL
SCHEMBL29733041 0.77 MEN1 (0.39) GPR84MEN1KMT2AKDM4ERECQL
SCHEMBL3919802 0.77 GPR84 (0.43) GPR84MEN1KMT2AKDM4ERECQL
SCHEMBL13436102 0.77 MEN1 (0.34) GPR84MEN1KMT2AKDM4E
SCHEMBL22256288 0.77
SCHEMBL22256419 0.77 MEN1 (0.36) GPR84MEN1KMT2AKDM4ERECQL
SCHEMBL25484835 0.77 MEN1 (0.39) GPR84MEN1KMT2AKDM4ERECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11664093-B2 Extrapolative prediction of enantioselectivity enabled by computer-driven workflow, new molecular representations and machine learning THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2023-05-30 US disclosed
US-11664093-B2 Extrapolative prediction of enantioselectivity enabled by computer-driven workflow, new molecular representations and machine learning THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2023-05-30 US disclosed
US-11664093-B2 Extrapolative prediction of enantioselectivity enabled by computer-driven workflow, new molecular representations and machine learning THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2023-05-30 US disclosed
US-20200234798-A1 EXTRAPOLATIVE PREDICTION OF ENANTIOSELECTIVITY ENABLED BY COMPUTER-DRIVEN WORKFLOW, NEW MOLECULAR REPRESENTATIONS AND MACHINE LEARNING THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 2020-07-23 US disclosed
US-20200234798-A1 EXTRAPOLATIVE PREDICTION OF ENANTIOSELECTIVITY ENABLED BY COMPUTER-DRIVEN WORKFLOW, NEW MOLECULAR REPRESENTATIONS AND MACHINE LEARNING THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 2020-07-23 US disclosed