Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 2/20 | 0.48 |
| ▸ | IDO1 | P14902 | 3/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | GPR6 | P46095 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2277699 | 0.88 | CXCR3 (0.51) | CXCR3ATMLMNASMN1; SMN2MEN1 | |
| SCHEMBL2266630 | 0.85 | CXCR3 (0.51) | CXCR3ATMLMNASMN1; SMN2HRH3 | |
| SCHEMBL2273750 | 0.84 | CXCR3 (0.49) | CXCR3IDO1GPR6LMNASMN1; SMN2 | |
| SCHEMBL12516595 | 0.84 | CXCR3 (0.55) | CXCR3ATMLMNASMN1; SMN2MEN1 | |
| SCHEMBL2271642 | 0.84 | CXCR3 (0.49) | CXCR3ATMLMNASMN1; SMN2MEN1 | |
| SCHEMBL2272027 | 0.84 | CXCR3 (0.49) | CXCR3ATMLMNASMN1; SMN2MEN1 | |
| SCHEMBL2265449 | 0.83 | CXCR3 (0.50) | CXCR3IDO1CCNE1CDK2LMNA | |
| SCHEMBL2276798 | 0.82 | CXCR3 (0.48) | CXCR3IDO1ATMCCNE1CDK2 | |
| SCHEMBL12515556 | 0.82 | CXCR3 (0.51) | CXCR3ATMLMNASMN1; SMN2MEN1 | |
| SCHEMBL2271313 | 0.82 | CXCR3 (0.55) | CXCR3ATMLMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084985-A1 | CXCR3 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-07-14 | — | — | WO | disclosed |