Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | ULK1 | O75385 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL914150 | 0.88 | ULK1 (0.67) | FLT3ULK1KMT2AMEN1RCE1 | |
| SCHEMBL30304098 | 0.86 | KDM4E (0.49) | FLT3KMT2AMEN1HDAC3HDAC1 | |
| SCHEMBL3616170 | 0.85 | SRD5A2 (0.59) | FLT3KMT2AMEN1RCE1HDAC3 | |
| SCHEMBL29943636 | 0.85 | SRD5A2 (0.59) | FLT3KMT2AMEN1RCE1HDAC3 | |
| SCHEMBL217459 | 0.84 | FLT3 (0.66) | FLT3ULK1KMT2AMEN1RCE1 | |
| SCHEMBL24019679 | 0.84 | KMT2A (0.59) | FLT3KMT2AMEN1RCE1HDAC3 | |
| SCHEMBL29943469 | 0.83 | FLT3 (0.48) | FLT3KMT2AMEN1RCE1HDAC3 | |
| SCHEMBL29063423 | 0.83 | HDAC3 (0.50) | FLT3KMT2AMEN1RCE1HDAC3 | |
| SCHEMBL31158902 | 0.81 | FLT3 (0.49) | FLT3ULK1KMT2AMEN1RCE1 | |
| SCHEMBL6308070 | 0.81 | FLT3 (0.51) | FLT3ULK1KMT2AMEN1RCE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3911653-A1 | SUBSTITUTED POLYCYCLIC CARBOXYLIC ACIDS, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2021-11-24 | — | — | EP | disclosed |
| WO-2020150366-A1 | SUBSTITUTED POLYCYCLIC CARBOXYLIC ACIDS, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2020-07-23 | — | — | WO | disclosed |