Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.48 |
| ▸ | CLK2 | P49760 | 5/20 | 0.48 |
| ▸ | CLK3 | P49761 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22236260 | 0.90 | CLK2 (0.55) | CD38DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22258274 | 0.82 | DYRK1A (0.59) | CD38DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22236191 | 0.81 | DYRK1A (0.55) | CD38DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22235987 | 0.81 | DYRK1A (0.59) | CD38DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22236050 | 0.79 | CLK2 (0.57) | CD38DYRK1ACLK2CLK3HTR2A | |
| SCHEMBL22235904 | 0.79 | CLK2 (0.57) | CD38DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22236124 | 0.79 | CLK2 (0.73) | CD38DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22235772 | 0.78 | CLK2 (0.75) | CD38DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22236013 | 0.78 | CLK2 (0.51) | CD38DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22235770 | 0.76 | DYRK1A (0.57) | CD38DYRK1ACLK2CLK3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |