Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 9/20 | 0.59 |
| ▸ | CLK2 | P49760 | 7/20 | 0.59 |
| ▸ | CLK3 | P49761 | 5/20 | 0.59 |
| ▸ | CD38 | P28907 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | WNT1 | P04628 | 4/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PIR | O00625 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22235987 | 0.90 | DYRK1A (0.59) | DYRK1ACLK2CLK3CD38ABL1 | |
| SCHEMBL22236050 | 0.90 | CLK2 (0.57) | DYRK1ACLK2CLK3CD38ABL1 | |
| SCHEMBL22235772 | 0.89 | CLK2 (0.75) | DYRK1ACLK2CLK3CD38ABL1 | |
| SCHEMBL22236260 | 0.88 | CLK2 (0.55) | DYRK1ACLK2CLK3CD38ABL1 | |
| SCHEMBL22236191 | 0.87 | DYRK1A (0.55) | DYRK1ACLK2CLK3CD38ABL1 | |
| SCHEMBL22235904 | 0.87 | CLK2 (0.57) | DYRK1ACLK2CLK3CD38ABL1 | |
| SCHEMBL22236124 | 0.83 | CLK2 (0.73) | DYRK1ACLK2CLK3CD38WNT1 | |
| SCHEMBL22236105 | 0.83 | KCNQ3 (0.55) | DYRK1ACLK2CLK3WNT1GSK3B | |
| SCHEMBL22236258 | 0.82 | CD38 (0.50) | DYRK1ACLK2CLK3CD38WNT1 | |
| SCHEMBL22236189 | 0.81 | DYRK1A (0.59) | DYRK1ACLK2CLK3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |