Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 9/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | MMP10 | P09238 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12802572 | 1.00 | CHRM1 (0.50) | CHRM1ADAM17MMP3MMP7MMP10 | |
| SCHEMBL6890523 | 0.91 | CHRM1 (0.44) | CHRM1ADAM17MMP3MMP7MMP10 | |
| SCHEMBL2223775 | 0.91 | CHRM1 (0.44) | CHRM1ADAM17MMP3MMP7MMP10 | |
| SCHEMBL2224921 | 0.84 | CNR2 (0.51) | — | |
| SCHEMBL2224924 | 0.84 | CNR2 (0.51) | — | |
| SCHEMBL2269430 | 0.84 | CNR2 (0.51) | — | |
| SCHEMBL2222196 | 0.84 | CNR2 (0.51) | — | |
| SCHEMBL12803099 | 0.83 | CHRM1 (0.47) | CHRM1NTRK1 | |
| SCHEMBL12802683 | 0.81 | ADAM17 (0.41) | ADAM17MMP3MMP7MMP10 | |
| SCHEMBL2224665 | 0.80 | CHRM1 (0.69) | CHRM1ADAM17MMP3MMP7MMP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512243-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |