Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | HTR1B | P28222 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18560976 | 0.84 | LMNA (0.46) | HTR1DHTR1BLMNAALDH1A1KDM4E | |
| SCHEMBL10609160 | 0.84 | TSHR (0.50) | HTR1DHTR1BLMNAALDH1A1KDM4E | |
| SCHEMBL15223497 | 0.80 | HTR1D (0.38) | HTR1DHTR1BALDH1A1TSHRKDM5A | |
| SCHEMBL24061839 | 0.80 | HTR1D (0.38) | HTR1DHTR1BLMNAALDH1A1KDM4E | |
| SCHEMBL25571334 | 0.78 | CA12 (0.41) | HTR1DHTR1BLMNAKDM4E | |
| SCHEMBL15618677 | 0.78 | HTR1D (0.37) | HTR1DHTR1BLMNAALDH1A1MEN1 | |
| SCHEMBL13485235 | 0.76 | HTR1D (0.36) | HTR1DHTR1BLMNAALDH1A1KDM4E | |
| SCHEMBL24508287 | 0.76 | TSHR (0.46) | HTR1DHTR1BMEN1KMT2ATSHR | |
| SCHEMBL20084554 | 0.76 | LMNA (0.47) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL15856940 | 0.76 | CNR2 (0.40) | HTR1DHTR1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512837-B1 | PYRIDINE AND PYRAZINE COMPOUNDS AS INHIBITORS OF RIPK2 | BOEHRINGER INGELHEIM INT (DE) | 2020-07-22 | — | — | EP | disclosed |