Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Toremifene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 9/20 | 0.88 |
| ▸ | ESR2 known ✓ | Q92731 | 2/20 | 0.77 |
| ▸ | HTR6 | P50406 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | ESRRG | P62508 | 15/20 | 0.88 |
| ▸ | ESRRA | P11474 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.72 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.72 |
| ▸ | EGFR | P00533 | 1/20 | 0.72 |
| ▸ | GBA1 | P04062 | 1/20 | 0.72 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | PRKCG | P05129 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | PRKCB | P05771 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Toremifene SCHEMBL7465 | 0.99 | HTR6 (1.00) | HTR6LMNAESRRGESR1ESR2 | |
| Toremifene SCHEMBL906278 | 0.99 | HTR6 (1.00) | HTR6LMNAESRRGESR1ESR2 | |
| Toremifene SCHEMBL1152000 | 0.99 | HTR6 (1.00) | HTR6LMNAESRRGESR1ESR2 | |
| 4-Hydroxytormifene SCHEMBL906309 | 0.94 | ESR1 (1.00) | HTR6LMNAESRRGESR1ESR2 | |
| SCHEMBL5736471 | 0.94 | HTR6 (0.91) | HTR6LMNAESRRGESR1ESR2 | |
| SCHEMBL5739418 | 0.94 | HTR6 (0.91) | HTR6LMNAESRRGESR1ESR2 | |
| 4-Hydroxytormifene SCHEMBL9099337 | 0.94 | ESR1 (1.00) | HTR6LMNAESRRGESR1ESR2 | |
| SCHEMBL5736463 | 0.94 | HTR6 (0.91) | HTR6LMNAESRRGESR1ESR2 | |
| SCHEMBL5737155 | 0.94 | HTR6 (0.91) | HTR6LMNAESRRGESR1ESR2 | |
| SCHEMBL5739474 | 0.94 | HTR6 (0.91) | HTR6LMNAESRRGESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109422810-A | The exploitation and application of full source of people or humanization bombesin receptor GRPR monoclonal antibody drug or diagnostic reagent | 孙立春 | 2019-03-05 | — | — | CN | disclosed |
| WO-2011085303-A1 | METHOD FOR HORMONE ABLATIVE THERAPY INDUCED OSTEOPOROSIS | GTX, INC. (US) | 2011-07-14 | — | — | WO | disclosed |