Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 10/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24270906 | 0.82 | GRIN2B (0.36) | GRIN2BHRH3GRIN1 | |
| SCHEMBL24270955 | 0.81 | GRIN2B (0.50) | GRIN2BGRIN1 | |
| SCHEMBL22239271 | 0.78 | GRIN2B (0.32) | GRIN2BGRIN1 | |
| SCHEMBL24270827 | 0.78 | GRIN2B (0.43) | GRIN2BHRH3GRIN1 | |
| SCHEMBL22239313 | 0.73 | HRH3 (0.39) | HRH3 | |
| SCHEMBL22239239 | 0.72 | GRIN2B (0.49) | GRIN2BGRIN1 | |
| SCHEMBL22239305 | 0.69 | GRIN2B (0.30) | GRIN2BHRH3 | |
| SCHEMBL26020752 | 0.69 | GRIN2B (0.45) | GRIN2BGRIN1 | |
| SCHEMBL22239315 | 0.69 | GRIN2B (0.45) | GRIN2BGRIN1 | |
| SCHEMBL26018022 | 0.67 | GRIN2B (0.48) | GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3683207-A1 | N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | Cadent Therapeutics, Inc. (US) | 2020-07-22 | — | — | EP | disclosed |