Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 18/20 | 0.80 |
| ▸ | VEGFA | P15692 | 7/20 | 0.80 |
| ▸ | FLT1 | P17948 | 7/20 | 0.80 |
| ▸ | EGLN3 | Q9H6Z9 | 5/20 | 0.80 |
| ▸ | TET3 | O43151 | 1/20 | 0.60 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.60 |
| ▸ | ASPH | Q12797 | 1/20 | 0.60 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.60 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.60 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.60 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.60 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22588827 | 0.90 | EGLN1 (0.81) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL1921387 | 0.89 | EGLN1 (1.00) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL30239178 | 0.89 | EGLN1 (1.00) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL24579666 | 0.88 | EGLN1 (0.78) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL30790421 | 0.88 | EGLN1 (0.78) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL29188896 | 0.86 | EGLN1 (0.75) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL21565675 | 0.83 | EGLN1 (0.71) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL23501725 | 0.83 | EGLN1 (0.71) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL3484916 | 0.81 | EGLN1 (0.82) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL20711144 | 0.80 | EGLN1 (0.80) | EGLN1VEGFAFLT1EGLN3TET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3683209-A1 | PROCESS FOR PREPARING [(5-(3-CHLOROPHENYL)-3-HYDROXYPYRIDINE-2-CARBONYL)-AMINO]ACETIC ACID FROM 5-((3-CHLOROPHENYL)-3-CHLORO-PYRIDIN-2-YL)-NITRILE, AND PROCESS FOR PREPARING 5-((HALOPHENYL)-3-HALO-PYRIDIN-2-YL)-NITRILE DERIVATIVES | Akebia Therapeutics Inc. (US) | 2020-07-22 | — | — | EP | disclosed |