Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 14/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22240030 | 0.95 | MME (0.44) | MMENR3C2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29078768 | 0.81 | NR3C2 (0.50) | MMENR3C2SMN1; SMN2 | |
| SCHEMBL22240064 | 0.80 | NR3C2 (0.41) | MMENR3C2 | |
| SCHEMBL11015263 | 0.78 | MME (0.43) | MMENR3C2NPC1RAB9A | |
| SCHEMBL23015674 | 0.76 | NR3C2 (0.55) | NR3C2 | |
| SCHEMBL5746344 | 0.74 | MME (0.41) | MMENR3C2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18469854 | 0.73 | KDM4E (0.46) | MMENR3C2SMN1; SMN2 | |
| SCHEMBL5746928 | 0.73 | NR3C2 (0.43) | MMENR3C2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22240180 | 0.73 | KDM4E (0.43) | MMENR3C2 | |
| SCHEMBL18599035 | 0.72 | SMN1; SMN2 (0.54) | NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |