Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 9/20 | 0.37 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22239757 | 0.87 | MEN1 (0.35) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22239858 | 0.86 | PHGDH (0.36) | PHGDHMAP3K12NPC1RAB9AMEN1 | |
| SCHEMBL22240094 | 0.85 | PHGDH (0.36) | PHGDHRAB9AKMT2A | |
| SCHEMBL22239941 | 0.83 | — | — | |
| SCHEMBL22239801 | 0.82 | — | — | |
| SCHEMBL19713766 | 0.78 | RPS6KA3 (0.39) | PHGDHMAP3K12NPC1RAB9AKMT2A | |
| SCHEMBL19736307 | 0.78 | RPS6KA3 (0.42) | MAP3K12NPC1RAB9AMEN1TP53 | |
| SCHEMBL22239936 | 0.77 | MEN1 (0.36) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22239708 | 0.76 | MEN1 (0.32) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL17776959 | 0.76 | ALOX15 (0.41) | NPC1RAB9AMEN1TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |