⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20288746 | 1.00 | — | — | |
| SCHEMBL28133251 | 0.84 | GBA1 (0.35) | — | |
| SCHEMBL3159738 | 0.81 | — | — | |
| SCHEMBL14972886 | 0.78 | — | — | |
| SCHEMBL23802873 | 0.74 | ALDH1A1 (0.36) | — | |
| SCHEMBL101769 | 0.74 | — | — | |
| SCHEMBL235448 | 0.74 | — | — | |
| SCHEMBL8421142 | 0.74 | ALDH1A1 (0.36) | — | |
| SCHEMBL20893 | 0.74 | — | — | |
| SCHEMBL2453706 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11021493-B2 | 1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use | AMGEN INC. (US) | 2021-06-01 | — | — | US | disclosed |
| US-10889581-B2 | Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use | AMGEN INC. (US) | 2021-01-12 | — | — | US | disclosed |
| US-20200231601-A1 | 1,4-THIAZINE DIOXIDE AND 1,2,4-THIADIAZINE DIOXIDE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | AMGEN INC. (US) | 2020-07-23 | — | — | US | disclosed |
| US-20200231585-A1 | CYCLOPROPYL FUSED THIAZINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | AMGEN INC. (US) | 2020-07-23 | — | — | US | disclosed |