Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 6/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 6/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22231535 | 0.92 | ALDH1A1 (0.43) | ALDH1A1HPGDCYP3A4MAPTKDM4E | |
| SCHEMBL22231534 | 0.92 | ALDH1A1 (0.43) | ALDH1A1HPGDCYP3A4MAPTKDM4E | |
| SCHEMBL22245040 | 0.92 | ALDH1A1 (0.44) | ALDH1A1HPGDCYP3A4MAPTKDM4E | |
| SCHEMBL22244939 | 0.88 | HPGD (0.39) | ALDH1A1HPGDCYP3A4MAPTKDM4E | |
| SCHEMBL28610302 | 0.88 | HPGD (0.39) | ALDH1A1HPGDCYP3A4MAPTKDM4E | |
| SCHEMBL22231241 | 0.88 | ALDH1A1 (0.44) | ALDH1A1HPGDCYP3A4MAPTKDM4E | |
| SCHEMBL21822978 | 0.86 | HPGD (0.41) | ALDH1A1HPGDCYP3A4MAPTKDM4E | |
| SCHEMBL21822521 | 0.86 | ALDH1A1 (0.43) | ALDH1A1HPGDCYP3A4MAPTKDM4E | |
| SCHEMBL30169704 | 0.86 | ALDH1A1 (0.43) | ALDH1A1HPGDCYP3A4MAPTKDM4E | |
| SCHEMBL21822666 | 0.85 | HPGD (0.52) | ALDH1A1HPGDCYP3A4MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213049-A1 | SUBSTITUTED CHROMEN-4-ONE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2022-07-07 | — | — | US | disclosed |
| CN-113301959-A | Substituted chromen-4-ones for the treatment and prevention of hepatitis B virus infection | 豪夫迈·罗氏有限公司 | 2021-08-24 | — | — | CN | disclosed |
| WO-2020148354-A1 | SUBSTITUTED CHROMEN-4-ONE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2020-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213049-A1 | SUBSTITUTED CHROMEN-4-ONE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HAVCR2, CYP26B1, CYP7A1 | ALDH1A1 420/4885HPGD 1900/4885CYP3A4 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.