Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14485572 | 0.81 | MAPT (0.57) | CCR8KCNH2KDM4EBCHEALDH1A1 | |
| SCHEMBL2224492 | 0.75 | MAPT (0.65) | CCR8KCNH2KDM4EALDH1A1MAPT | |
| SCHEMBL2225418 | 0.75 | MAPT (0.55) | CCR8KCNH2KDM4EMAPK1HTR7 | |
| SCHEMBL2225865 | 0.74 | MAPT (0.57) | CCR8KCNH2KDM4EHTR2AALDH1A1 | |
| SCHEMBL2224288 | 0.73 | HTR3E (0.50) | KDM4EHTR1AHTR3EHTR3BHTR2C | |
| SCHEMBL14485560 | 0.73 | HTR3E (0.50) | KDM4EHTR1AHTR3EHTR3BHTR2C | |
| SCHEMBL2223004 | 0.73 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2LMNAALOX12 | |
| SCHEMBL2221291 | 0.72 | KDM4E (0.52) | KDM4EHTR1AHTR3EHTR3BHTR2C | |
| SCHEMBL2224409 | 0.72 | MAPT (0.52) | KDM4EHTR1AHTR7HTR6MAPT | |
| SCHEMBL2224449 | 0.71 | HTR3E (0.47) | KDM4EHTR1AHTR3EHTR3BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523665-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | Glaxo Group Limited (GB) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088201-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-07-21 | — | — | WO | disclosed |