Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | GALR3 | O60755 | 1/20 | 0.50 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15014120 | 0.77 | NPC1 (0.72) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL13210620 | 0.76 | NPC1 (0.67) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL13515550 | 0.75 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL2915657 | 0.75 | TRPV1 (0.72) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL2019464 | 0.74 | POLB (0.70) | NPC1RAB9ASMN1; SMN2ALDH1A1TRPV1 | |
| SCHEMBL15094124 | 0.74 | CA12 (0.74) | NPC1RAB9ASMN1; SMN2ALDH1A1TRPV1 | |
| SCHEMBL31277872 | 0.73 | NPC1 (0.63) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL31277665 | 0.73 | NPC1 (0.63) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL2748237 | 0.73 | POLB (0.73) | NPC1RAB9ASMN1; SMN2ALDH1A1TRPV1 | |
| SCHEMBL27644948 | 0.73 | POLB (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230106899-A1 | METHODS OF TREATING CANCER | NOVARTIS PHARMA AG (CH) | 2023-04-06 | — | — | US | disclosed |
| WO-2020150417-A2 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | IFM DUE, INC. (US) | 2020-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230106899-A1 | METHODS OF TREATING CANCER | STING1, CGAS, TBK1 | NPC1 249/4885RAB9A 1457/4885LMNA 1575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.