Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224728 | 1.00 | HDAC1 (0.38) | HDAC1HDAC8HDAC6LMNASCN9A | |
| SCHEMBL2224739 | 0.82 | HDAC8 (0.39) | HDAC1HDAC8HDAC6LMNASCN9A | |
| SCHEMBL2265476 | 0.79 | GAA (0.39) | HDAC1HDAC8HDAC6LMNASCN9A | |
| SCHEMBL2265468 | 0.79 | GAA (0.39) | HDAC1HDAC8HDAC6LMNASCN9A | |
| SCHEMBL2223878 | 0.76 | HDAC4 (0.37) | HDAC1HDAC8HDAC6LMNASCN9A | |
| SCHEMBL2223339 | 0.76 | HDAC8 (0.43) | HDAC1HDAC8HDAC6LMNASCN9A | |
| SCHEMBL2222335 | 0.73 | HDAC8 (0.44) | HDAC1HDAC8HDAC6LMNASCN9A | |
| SCHEMBL2221125 | 0.71 | HDAC4 (0.38) | HDAC1HDAC8HDAC6 | |
| SCHEMBL2224731 | 0.71 | HDAC8 (0.38) | HDAC1HDAC8HDAC6LMNASCN9A | |
| SCHEMBL2224737 | 0.69 | HDAC8 (0.40) | HDAC1HDAC8HDAC6LMNAPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523560-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088187-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |