Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222405 | 0.83 | HDAC1 (0.42) | HDAC8HDAC1HDAC6LMNASCN9A | |
| SCHEMBL2224718 | 0.82 | HDAC1 (0.38) | HDAC8HDAC1HDAC6LMNASCN9A | |
| SCHEMBL2224728 | 0.82 | HDAC1 (0.38) | HDAC8HDAC1HDAC6LMNASCN9A | |
| SCHEMBL2224731 | 0.78 | HDAC8 (0.38) | HDAC8HDAC1HDAC6LMNASCN9A | |
| SCHEMBL2223878 | 0.77 | HDAC4 (0.37) | HDAC8HDAC1HDAC6LMNASCN9A | |
| SCHEMBL2223339 | 0.76 | HDAC8 (0.43) | HDAC8HDAC1HDAC6LMNASCN9A | |
| SCHEMBL2224737 | 0.76 | HDAC8 (0.40) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2223402 | 0.75 | LMNA (0.44) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2266329 | 0.75 | GAA (0.40) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2222335 | 0.74 | HDAC8 (0.44) | HDAC8HDAC1HDAC6LMNASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088187-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |