Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.56 |
| ▸ | MC4R | P32245 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1974665 | 1.00 | RORC (0.56) | RORCMC4RSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27405331 | 1.00 | RORC (0.56) | RORCMC4RSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2778336 | 1.00 | RORC (0.56) | RORCMC4RSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2782125 | 1.00 | RORC (0.56) | RORCMC4RSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2224784 | 1.00 | RORC (0.56) | RORCMC4RSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2778339 | 1.00 | RORC (0.56) | RORCMC4RSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1920333 | 1.00 | RORC (0.56) | RORCMC4RSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4661703 | 0.92 | RORC (0.57) | RORCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5110560 | 0.92 | RORC (0.57) | RORCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14498495 | 0.92 | RORC (0.57) | RORCSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513052-A1 | PYRROLIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| EP-2398768-A1 | PYRROLIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-12-28 | — | — | EP | disclosed |
| WO-2011085886-A1 | PYRROLIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |
| WO-2010094667-A1 | PYRROLIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-08-26 | — | — | WO | disclosed |