Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 3/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.36 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 4/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22272972 | 0.88 | TYK2 (0.55) | TYK2HRH4P2RY12MAP3K12NAPEPLD | |
| SCHEMBL25069778 | 0.85 | TYK2 (0.49) | TYK2HRH4P2RY12MAP3K12NAPEPLD | |
| SCHEMBL20697164 | 0.85 | TYK2 (0.49) | TYK2HRH4P2RY12MAP3K12ACACB | |
| SCHEMBL23583130 | 0.82 | TYK2 (0.47) | TYK2HRH4P2RY12MAP3K12ACACB | |
| SCHEMBL20689537 | 0.80 | TYK2 (0.48) | TYK2HRH4MAP3K12ACACBMAP4K4 | |
| SCHEMBL20697366 | 0.74 | TYK2 (0.45) | TYK2HRH4MAP3K12NAPEPLDLRRK2 | |
| SCHEMBL24370192 | 0.73 | PIK3CD (0.45) | TYK2HRH4MAP3K12ACACBMAP4K4 | |
| SCHEMBL24370196 | 0.73 | PIK3CD (0.45) | TYK2HRH4MAP3K12ACACBMAP4K4 | |
| SCHEMBL12494898 | 0.73 | PIK3CD (0.45) | TYK2HRH4MAP3K12ACACBMAP4K4 | |
| SCHEMBL20688035 | 0.69 | TYK2 (0.54) | TYK2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11174264-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2021-11-16 | — | — | US | disclosed |
| US-20200231594-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11174264-B2 | TYK2 inhibitors and uses thereof | TYK2, JAK2, JAK1 | TYK2 1/4885HRH4 2233/4885P2RY12 3554/4885 |
| US-20200231594-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | TYK2 1/4885HRH4 2233/4885P2RY12 3554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.