Terephthalic Acid

Terephthalic Acid

SCHEMBL222545

O=C(O)c1ccc(C(=O)O)cc1.O=C(O)c1cccc(C(=O)Oc2cccc(O)c2)c1

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

OPRM1

The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 4/20 0.66
ESR2 Q92731 3/20 0.66
CA12 O43570 1/20 0.58
CA1 P00915 1/20 0.58
CA2 P00918 1/20 0.58
CA6 P23280 1/20 0.58
CA9 Q16790 1/20 0.58
CYP3A4 P08684 1/20 0.51
KMT2A Q03164 4/20 0.50
MEN1 O00255 2/20 0.50
CASP3 P42574 1/20 0.50
SENP8 Q96LD8 1/20 0.50
SENP7 Q9BQF6 1/20 0.50
SENP6 Q9GZR1 1/20 0.50
AKR1C3 P42330 1/20 0.47
SERPINE1 P05121 1/20 0.47
NR4A2 P43354 1/20 0.45
MAPT P10636 3/20 0.45
TDP1 Q9NUW8 2/20 0.45
NSD2 O96028 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isophthalic Acid SCHEMBL7099350 0.97 ESR1 (0.61) ESR1ESR2CA12CA1CA2
SCHEMBL29905095 0.97 ESR1 (0.69) ESR1ESR2CA12CA1CA2
SCHEMBL3172439 0.97 ESR1 (0.69) ESR1ESR2CA12CA1CA2
SCHEMBL4640725 0.92 ESR1 (0.62) ESR1ESR2CA12CA1CA2
SCHEMBL21114373 0.90 ESR1 (0.69) ESR1ESR2CA12CA1CA2
SCHEMBL689959 0.90 ESR1 (0.78) ESR1ESR2CA12CA1CA2
Terephthalic Acid SCHEMBL15206567 0.89 CA12 (0.59) ESR1ESR2CA12CA1CA2
SCHEMBL904445 0.89 KMT2A (0.53) ESR1ESR2KMT2AMEN1AKR1C3
SCHEMBL8205804 0.87 CA12 (0.61) ESR1ESR2CA12CA1CA2
Terephthalic Acid SCHEMBL6660728 0.87 AKR1C3 (0.58) KMT2AMEN1AKR1C3NR4A2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 676 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110382592-B Polycarbonate copolymers, articles formed therefrom, and methods of manufacture 沙特基础工业全球技术有限公司 2021-03-26 CN claimed
US-20120287556-A1 AMORPHOUS POLYCARBONATE FILMS FOR CAPACITORS, METHODS OF MANUFACTURE, AND ARTICLES MANUFACTURED THEREFROM SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2012-11-15 US claimed
EP-1171513-B1 WEATHERABLE MULTILAYER RESINOUS ARTICLES AND METHOD FOR THEIR PREPARATION GEN ELECTRIC (US) 2008-08-13 EP claimed
EP-1240244-B1 COLOR STABLE POLYARYLATE-CONTAINING COMPOSITIONS GEN ELECTRIC (US) 2006-01-18 EP claimed
EP-1228133-B1 RESINOUS COMPOSITIONS CONTAINING BLUE DYE GEN ELECTRIC (US) 2005-11-02 EP claimed
US-20030207096-A1 Weatherable multilayer resinous articles and method for their prepartion SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2003-11-06 US claimed
EP-1216276-B1 WEATHERABLE COLORED RESIN COMPOSITIONS GEN ELECTRIC (US) 2003-07-09 EP claimed
US-6572956-B1 Protective coating of such as resorcinol, isophthalic acid and terephthalic acid copolyester; photoyellowing resistance; gloss retention; solvent resistance; recyclability GENERAL ELECTRIC COMPANY 2003-06-03 US claimed
EP-1115792-B1 WEATHERABLE BLENDS OF POLYCARBONATES WITH ARYLATE POLYMERS GEN ELECTRIC (US) 2003-04-23 EP claimed
JP-2002542325-A 2002-12-10 JP claimed
EP-1216276-A1 WEATHERABLE COLORED RESIN COMPOSITIONS GENERAL ELECTRIC COMPANY (US) 2002-06-26 EP claimed
EP-1171513-A1 WEATHERABLE MULTILAYER RESINOUS ARTICLES AND METHOD FOR THEIR PREPARATION GENERAL ELECTRIC COMPANY (US) 2002-01-16 EP claimed
EP-1115792-A1 WEATHERABLE BLENDS OF POLYCARBONATES WITH ARYLATE POLYMERS GENERAL ELECTRIC COMPANY (US) 2001-07-18 EP claimed
US-6245118-B1 ARYLATE POLYMERS CONTAINING 2,3-DICYANO-1,4-DIAMINOANTHRAQUINONE AS A BLUE DYE; IMPROVED WEATHERABILITY GENERAL ELECTRIC COMPANY 2001-06-12 US claimed
WO-2001019921-A1 WEATHERABLE COLORED RESIN COMPOSITIONS GENERAL ELECTRIC COMPANY (US) 2001-03-22 WO claimed
WO-2001018104-A1 RESINOUS COMPOSITIONS CONTAINING BLUE DYE GENERAL ELECTRIC COMPANY (US) 2001-03-15 WO claimed
WO-2001018103-A1 COLOR STABLE POLYARYLATE-CONTAINING COMPOSITIONS GENERAL ELECTRIC COMPANY (US) 2001-03-15 WO claimed
US-6143839-A THERMOPLASTIC ARYLATE POLYMER COMPRISING UNITS DERIVED FROM A RESORCINOL OR ALKYLRESORCINOL ISOPHTHALATE-TEREPHTHALATE IMPROVES COLOR STABILITY OR GLOSS RETENTION OF THE POLYCARBONATE; ARTICLES MADE FROM THE BLEND GENERAL ELECTRIC COMPANY (US) 2000-11-07 US claimed
WO-2000061664-A1 WEATHERABLE MULTILAYER RESINOUS ARTICLES AND METHOD FOR THEIR PREPARATION GENERAL ELECTRIC COMPANY (US) 2000-10-19 WO claimed
WO-2000015718-A1 WEATHERABLE BLENDS OF POLYCARBONATES WITH ARYLATE POLYMERS GENERAL ELECTRIC COMPANY (US) 2000-03-23 WO claimed