Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.54 |
| ▸ | NSD2 | O96028 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | ACR | P10323 | 1/20 | 0.49 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL10678592 | 0.98 | MAPT (0.57) | AKR1C3MAPTALDH1A1TDP1PARP10 | |
| SCHEMBL995523 | 0.96 | AKR1C3 (0.61) | AKR1C3MAPTALDH1A1TDP1PARP10 | |
| Isophthalic Acid SCHEMBL2889737 | 0.95 | PARP10 (0.61) | AKR1C3MAPTALDH1A1TDP1PARP10 | |
| SCHEMBL11040365 | 0.93 | PARP10 (0.59) | AKR1C3MAPTALDH1A1TDP1PARP10 | |
| SCHEMBL28455036 | 0.93 | AKR1C3 (0.58) | AKR1C3MAPTALDH1A1TDP1PARP10 | |
| SCHEMBL11273083 | 0.93 | PARP10 (0.58) | MAPTALDH1A1TDP1PARP10NSD2 | |
| SCHEMBL904445 | 0.91 | KMT2A (0.53) | AKR1C3MAPTALDH1A1TDP1PARP10 | |
| SCHEMBL10664572 | 0.91 | PARP10 (0.65) | MAPTALDH1A1TDP1PARP10NSD2 | |
| SCHEMBL8848151 | 0.91 | LMNA (0.56) | AKR1C3MAPTALDH1A1TDP1PARP10 | |
| SCHEMBL69684 | 0.91 | NSD2 (0.63) | AKR1C3MAPTALDH1A1TDP1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095960-B1 | SYSTEM AND PROCESS FOR PRODUCING POLYCONDENSATION POLYMER | ASAHI CHEMICAL IND (JP) | 2004-08-25 | — | — | EP | disclosed |
| US-6265526-B1 | SYSTEM COMPRISING INERT GAS ABSORPTION DEVICE FOR CAUSING MOLTEN POLYCONDENSATION PREPOLYMER TO ABSORB INERT GAS AND POLYMERIZER DEVICE FOR POLYMERIZING INERT GAS-ABSORBED MOLTEN PREPOLYMER UNDER REDUCED PRESSURE CONNECTED BY TRANSFER PIPE | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2001-07-24 | — | — | US | disclosed |
| EP-1095960-A1 | SYSTEM AND PROCESS FOR PRODUCING POLYCONDENSATION POLYMER | Asahi Kasei Kabushiki Kaisha (JP) | 2001-05-02 | — | — | EP | disclosed |