Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12659569 | 0.81 | MDM4 (0.40) | KMT2ASMN1; SMN2MEN1HTTPKM | |
| SCHEMBL3588865 | 0.74 | KMT2A (0.45) | KMT2ASMN1; SMN2MEN1HTTPKM | |
| SCHEMBL22235741 | 0.73 | PDPK1 (0.61) | KMT2ASMN1; SMN2MEN1PKMKDM4E | |
| SCHEMBL23719197 | 0.73 | KMT2A (0.59) | KMT2ASMN1; SMN2MEN1HTTPKM | |
| SCHEMBL22828397 | 0.73 | TRPV1 (0.47) | — | |
| SCHEMBL22828392 | 0.71 | EPHX1 (0.42) | KMT2ASMN1; SMN2MEN1HTTPKM | |
| SCHEMBL23719133 | 0.71 | MTNR1A (0.48) | KMT2AMEN1KDM4E | |
| SCHEMBL13314757 | 0.70 | KMT2A (0.54) | KMT2ASMN1; SMN2MEN1HTTPKM | |
| SCHEMBL22828681 | 0.69 | KMT2A (0.44) | KMT2ASMN1; SMN2MEN1HTTPKM | |
| SCHEMBL10240043 | 0.69 | KDM4E (0.48) | KMT2ASMN1; SMN2MEN1HTTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |