Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.49 |
| ▸ | CLK2 | P49760 | 5/20 | 0.49 |
| ▸ | CLK3 | P49761 | 3/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.33 |
| ▸ | WNT1 | P04628 | 2/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22258821 | 0.88 | DYRK1A (0.48) | DYRK1ACLK2CLK3CRBNCACNA1H | |
| SCHEMBL22258449 | 0.87 | DYRK1A (0.47) | DYRK1ACLK2CLK3CRBNCACNA1H | |
| SCHEMBL22258230 | 0.87 | NPC1 (0.40) | DYRK1ACLK2CLK3WNT1HDAC3 | |
| SCHEMBL22258478 | 0.86 | NPC1 (0.41) | DYRK1ACLK2CLK3WNT1HDAC1 | |
| SCHEMBL22258825 | 0.86 | CLK2 (0.40) | DYRK1ACLK2CLK3CRBNCACNA1H | |
| SCHEMBL22235747 | 0.85 | CLK2 (0.55) | DYRK1ACLK2CLK3WNT1CRACR2A | |
| SCHEMBL22258263 | 0.84 | DYRK1A (0.65) | DYRK1ACLK2CLK3CRBNCACNA1H | |
| SCHEMBL22258536 | 0.81 | DYRK1A (0.47) | DYRK1ACLK2CLK3CACNA1HWNT1 | |
| SCHEMBL22258448 | 0.78 | LMNA (0.46) | DYRK1ACLK2CLK3 | |
| SCHEMBL22258452 | 0.77 | CLK2 (0.43) | DYRK1ACLK2CRACR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |