Bromide

Bromide

SCHEMBL22263140

Br.Br.N=C(N)SCc1ccc(F)cc1CSC(=N)N

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 10/20 0.59
MAPT P10636 1/20 0.55
HTT P42858 5/20 0.54
ATP1A1 P05023 1/20 0.49
ATP1B1 P05026 1/20 0.49
ATP1A3 P13637 1/20 0.49
ATP1B2 P14415 1/20 0.49
ATP1A2 P50993 1/20 0.49
ATP1B3 P54709 1/20 0.49
FXYD2 P54710 1/20 0.49
ATP1A4 Q13733 1/20 0.49
NOS1 P29475 2/20 0.48
LMNA P02545 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
TAAR1 Q96RJ0 2/20 0.46
SLC11A2 P49281 1/20 0.46
ALDH1A1 P00352 2/20 0.45
ALDH3A1 P30838 2/20 0.45
NOS3 P29474 1/20 0.44
NOS2 P35228 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22275619 0.98 IDO1 (0.61) IDO1MAPTHTTATP1A1ATP1B1
SCHEMBL3769133 0.86 IDO1 (0.59) IDO1MAPTHTTATP1A1ATP1B1
Bromide SCHEMBL4442763 0.85 IDO1 (0.54) IDO1MAPTHTTATP1A1ATP1B1
Bromide SCHEMBL4439226 0.83 IDO1 (0.53) IDO1MAPTHTTATP1A1ATP1B1
Bromide SCHEMBL4442320 0.83 IDO1 (0.49) IDO1MAPTHTTATP1A1ATP1B1
SCHEMBL3684003 0.83 IDO1 (0.56) IDO1MAPTHTTATP1A1ATP1B1
SCHEMBL13256328 0.83 IDO1 (0.71) IDO1MAPTHTTNOS1LMNA
Bromide SCHEMBL4445135 0.82 IDO1 (0.47) IDO1MAPTHTTATP1A1ATP1B1
SCHEMBL3688866 0.81 IDO1 (0.54) IDO1MAPTHTTATP1A1ATP1B1
SCHEMBL3685699 0.81 IDO1 (0.50) IDO1MAPTHTTATP1A1ATP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250092020-A1 IDO/TDO Inhibitor GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP) 2025-03-20 US disclosed
US-12209079-B2 IDO/TDO inhibitor GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP) 2025-01-28 US disclosed
US-20220380305-A1 IDO/TDO Inhibitor CANBAS CO., LTD. 2022-12-01 US disclosed
US-20200239452-A1 IDO/TDO Inhibitor CANBAS CO., LTD. (JP) 2020-07-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12209079-B2 IDO/TDO inhibitor IDO1, IDO2, TDO2 IDO1 1/4885MAPT 609/4885HTT 71/4885
US-20200239452-A1 IDO/TDO Inhibitor IDO1, IDO2, TDO2 IDO1 1/4885MAPT 609/4885HTT 71/4885
US-20250092020-A1 IDO/TDO Inhibitor IDO1, IDO2, TDO2 IDO1 1/4885MAPT 609/4885HTT 71/4885
US-20220380305-A1 IDO/TDO Inhibitor IDO1, IDO2, TDO2 IDO1 1/4885MAPT 614/4885HTT 100/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.