SCHEMBL22263540

SCHEMBL22263540

CC(=O)O[C@H]1C[C@@H](O)[C@H](/C=C/C(O)C(C)CC#CC2CC2)[C@H]1CCCC/C=C/C(=O)O

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ PDE4D Q08499 7/20 0.37
▸ PTGER1 P34995 3/20 0.36
▸ PTGER3 P43115 3/20 0.36
▸ PTGIR P43119 2/20 0.36
▸ PTGDR Q13258 2/20 0.36
▸ PTGER2 P43116 1/20 0.36
▸ ALDH1A1 P00352 3/20 0.32
▸ TBXA2R P21731 2/20 0.30
▸ PTGFR P43088 2/20 0.30
▸ LMNA P02545 1/20 0.30
▸ PTGER4 P35408 1/20 0.30
▸ SLCO2A1 Q92959 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22263537 1.00 PDE4D (0.37) PDE4DPTGER1PTGER3PTGIRPTGDR
SCHEMBL28457532 1.00 PDE4D (0.37) PDE4DPTGER1PTGER3PTGIRPTGDR
SCHEMBL22278903 0.92 PDE4D (0.39) PDE4DPTGER1PTGER3PTGIRPTGDR
SCHEMBL22278867 0.92 PDE4D (0.39) PDE4DPTGER1PTGER3PTGIRPTGDR
SCHEMBL20815455 0.84 PDE4D (0.44) PDE4DPTGER1PTGER3PTGIRPTGDR
SCHEMBL20815457 0.84 PDE4D (0.44) PDE4DPTGER1PTGER3PTGIRPTGDR
SCHEMBL20991777 0.80 PTGER1 (0.32) PTGER1PTGER3PTGIRPTGDRPTGER2
SCHEMBL20991861 0.80 PDE4D (0.40) PDE4DPTGER1PTGER3PTGIRPTGDR
SCHEMBL20815491 0.78 PTGIR (0.43) PDE4DPTGER1PTGER3PTGIRPTGDR
SCHEMBL20815490 0.78 PTGIR (0.43) PDE4DPTGER1PTGER3PTGIRPTGDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3705472-B1 METHOD FOR PRODUCING PROSTAGLANDIN DERIVATIVE AGC INC (JP) 2023-06-21 — — EP disclosed
US-11377413-B2 Method for producing prostaglandin derivative AGC Inc. (JP) 2022-07-05 — — US disclosed
US-20200239397-A1 METHOD FOR PRODUCING PROSTAGLANDIN DERIVATIVE AGC Inc. (JP) 2020-07-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11377413-B2 Method for producing prostaglandin derivative PTGS1, PTGIS, PTGER1 PDE4D 340/4885PTGER1 3/4885PTGER3 10/4885
US-20200239397-A1 METHOD FOR PRODUCING PROSTAGLANDIN DERIVATIVE PTGS1, PTGIS, PTGER1 PDE4D 340/4885PTGER1 3/4885PTGER3 10/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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