Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 14/20 | 0.73 |
| ▸ | BCL2 | P10415 | 9/20 | 0.73 |
| ▸ | MDM4 | O15151 | 1/20 | 0.73 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | BID | P55957 | 1/20 | 0.73 |
| ▸ | BAX | Q07812 | 1/20 | 0.73 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.73 |
| ▸ | ASPH | Q12797 | 1/20 | 0.73 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.73 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.73 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.73 |
| ▸ | BAD | Q92934 | 1/20 | 0.73 |
| ▸ | BBC3 | Q9BXH1 | 1/20 | 0.73 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738074 | 0.91 | HDAC3 (0.76) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| SCHEMBL4739285 | 0.90 | HDAC3 (0.77) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| SCHEMBL4737770 | 0.90 | HDAC3 (0.77) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| SCHEMBL1541470 | 0.89 | BCL2L1 (0.84) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| SCHEMBL2022327 | 0.89 | BCL2L1 (0.80) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| SCHEMBL21437307 | 0.87 | BCL2L1 (0.80) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| SCHEMBL570848 | 0.87 | BCL2L1 (0.74) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| SCHEMBL1540259 | 0.86 | BCL2L1 (0.87) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| SCHEMBL17080401 | 0.86 | BCL2L1 (0.66) | BCL2L1BCL2MDM4BCL2L11TP53 | |
| SCHEMBL18229918 | 0.86 | BCL2L1 (0.74) | BCL2L1BCL2MDM4BCL2L11TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192183-A1 | PHARMACEUTICAL COMBINATIONS AND METHODS OF USE OF AMINO-PYRROLOPYRIMIDINONE COMPOUND | MERCK SHARP & DOHME LLC (US) | 2023-10-05 | — | — | WO | claimed |
| US-20200239486-A1 | PYRIMIDINE-BASED COMPOUNDS FOR THE TREATMENT OF CANCER | G1 THERAPEUTICS, INC. (US) | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200239486-A1 | PYRIMIDINE-BASED COMPOUNDS FOR THE TREATMENT OF CANCER | TYMS, TYMP, DPYD | BCL2L1 2163/4885BCL2 1328/4885MDM4 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.