Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 5/20 | 0.77 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.77 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.77 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.77 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.77 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.77 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.77 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.77 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.77 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.77 |
| ▸ | BCL2L1 | Q07817 | 14/20 | 0.67 |
| ▸ | BCL2 | P10415 | 9/20 | 0.67 |
| ▸ | MDM4 | O15151 | 1/20 | 0.67 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | BID | P55957 | 1/20 | 0.67 |
| ▸ | BAX | Q07812 | 1/20 | 0.67 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.67 |
| ▸ | ASPH | Q12797 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737770 | 1.00 | HDAC3 (0.77) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4738074 | 0.99 | HDAC3 (0.76) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL22264451 | 0.90 | BCL2L1 (0.73) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4737122 | 0.87 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4903627 | 0.87 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4737137 | 0.87 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4737148 | 0.87 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4737768 | 0.86 | HDAC3 (0.76) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4741299 | 0.86 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4741285 | 0.86 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |