SCHEMBL22265487

SCHEMBL22265487

CCCCCCCCNc1ccc(-c2noc(C3CCN(C(=O)O)C3)n2)cn1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.49
CYP1A2 P05177 1/20 0.49
POLB P06746 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
HSD11B1 P28845 6/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
SPHK2 Q9NRA0 2/20 0.45
SPHK1 Q9NYA1 1/20 0.45
HCAR3 P49019 1/20 0.44
TUBB4A P04350 2/20 0.43
TUBB P07437 2/20 0.43
TUBA3C P0DPH7 2/20 0.43
TUBA1B P68363 2/20 0.43
TUBA4A P68366 2/20 0.43
TUBB4B P68371 2/20 0.43
TUBB3 Q13509 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22265480 1.00 HTT (0.49) HTTCYP1A2POLBCYP3A4CYP2D6
Hydrochloric Acid SCHEMBL22265409 0.88 SPHK2 (0.56) HTTCYP1A2POLBCYP3A4CYP2D6
Hydrochloric Acid SCHEMBL22265416 0.88 SPHK2 (0.56) HTTCYP1A2POLBCYP3A4CYP2D6
SCHEMBL22265356 0.85 SPHK2 (0.53) HTTCYP1A2POLBCYP3A4CYP2D6
SCHEMBL22265353 0.85 SPHK2 (0.53) HTTCYP1A2POLBCYP3A4CYP2D6
SCHEMBL22265447 0.83 SPHK2 (0.49) HTTCYP1A2POLBCYP3A4CYP2D6
SCHEMBL22265444 0.83 SPHK2 (0.49) HTTCYP1A2POLBCYP3A4CYP2D6
SCHEMBL26690863 0.83 CYP1A2 (0.54) HTTCYP1A2POLBCYP3A4CYP2D6
SCHEMBL26690860 0.83 CYP1A2 (0.54) HTTCYP1A2POLBCYP3A4CYP2D6
SCHEMBL22265411 0.81 SPHK2 (0.68) HTTCYP1A2POLBCYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3914592-A1 INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY University of Virginia Patent Foundation (US) 2021-12-01 EP disclosed
WO-2020154431-A1 INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY LYNCH KEVIN R (US) 2020-07-30 WO disclosed