Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 7/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.45 |
| ▸ | MGLL | Q99685 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | FAAH | O00519 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19257599 | 0.87 | PTGS1 (0.48) | PTGS1PTGS2MGLLSMN1; SMN2HPGD | |
| SCHEMBL19708967 | 0.83 | PTGS1 (0.49) | PTGS1PTGS2MGLLSMN1; SMN2HPGD | |
| SCHEMBL22267884 | 0.82 | PTGS1 (0.43) | PTGS1PTGS2MGLLSMN1; SMN2HPGD | |
| SCHEMBL18596603 | 0.82 | PTGS1 (0.43) | PTGS1PTGS2MGLLSMN1; SMN2HPGD | |
| SCHEMBL18596600 | 0.82 | PTGS1 (0.43) | PTGS1PTGS2MGLLSMN1; SMN2HPGD | |
| SCHEMBL18515923 | 0.81 | PTGS1 (0.42) | PTGS1PTGS2MGLLSMN1; SMN2HPGD | |
| SCHEMBL25965248 | 0.81 | PTGS1 (0.42) | PTGS1PTGS2MGLLSMN1; SMN2HPGD | |
| SCHEMBL22267880 | 0.80 | PTGS1 (0.38) | PTGS1PTGS2MGLLSMN1; SMN2HPGD | |
| SCHEMBL25748815 | 0.79 | PTGS1 (0.50) | PTGS1PTGS2MGLLSMN1; SMN2HPGD | |
| SCHEMBL25748817 | 0.79 | PTGS1 (0.50) | PTGS1PTGS2MGLLSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10723727-B2 | Tubulysin analogs and methods for their preparation | PFIZER INC. (US) | 2020-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10723727-B2 | Tubulysin analogs and methods for their preparation | NGLY1, TEK, TEKT1 | PTGS1 4670/4885PTGS2 4790/4885MGLL 4563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.