Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.33 |
| ▸ | CA9 | Q16790 | 4/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.32 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.32 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.32 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2227346 | 0.77 | MAP3K7 (0.34) | CCNCCDK8MEN1KMT2ANTRK1 | |
| SCHEMBL12444936 | 0.73 | NFATC1 (0.47) | DYRK1ANFATC1GSK3BRAB9ANTRK1 | |
| SCHEMBL2226838 | 0.73 | NFATC1 (0.47) | DYRK1ANFATC1GSK3BRAB9ANTRK1 | |
| SCHEMBL2227996 | 0.71 | NFATC1 (0.56) | DYRK1ANFATC1GSK3BNTRK1 | |
| SCHEMBL6363702 | 0.70 | CCNC (0.55) | CCNCCDK8MEN1KMT2ARAB9A | |
| SCHEMBL16827890 | 0.70 | CCNC (0.55) | CCNCCDK8MEN1KMT2ARAB9A | |
| SCHEMBL12889390 | 0.68 | DYRK1A (0.64) | DYRK1ANFATC1GSK3BUSP2NTRK1 | |
| SCHEMBL21917358 | 0.67 | DYRK1A (0.62) | DYRK1ANFATC1GSK3BUSP2NTRK1 | |
| SCHEMBL21917172 | 0.67 | DYRK1A (0.62) | DYRK1ANFATC1GSK3BUSP2NTRK1 | |
| SCHEMBL12874842 | 0.67 | DYRK1A (0.62) | DYRK1ANFATC1GSK3BUSP2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183975-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | GOTO YASUHIRO | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183975-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | BRIX1, REL, CNKSR1 | DYRK1A 1517/4885NFATC1 547/4885GSK3B 2618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.