Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.81 |
| ▸ | ACVR1B | P36896 | 19/20 | 0.81 |
| ▸ | ACVRL1 | P37023 | 13/20 | 0.81 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16888494 | 0.90 | TGFBR1 (1.00) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16879640 | 0.90 | TGFBR1 (1.00) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16879186 | 0.82 | TGFBR1 (0.72) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16879264 | 0.79 | TGFBR1 (1.00) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16879467 | 0.79 | TGFBR1 (1.00) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16879744 | 0.78 | TGFBR1 (1.00) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16879742 | 0.78 | TGFBR1 (1.00) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL18219798 | 0.76 | TGFBR1 (0.79) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL20397410 | 0.76 | TGFBR1 (0.79) | TGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16888478 | 0.76 | TGFBR1 (0.76) | TGFBR1ACVR1BACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3089971-B1 | COMPOUNDS AND METHODS OF USE | MEDIVATION TECH LLC (US) | 2020-07-29 | — | — | EP | disclosed |