Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31226269 | 0.95 | KDM4E (0.49) | EPHX2ADRA1APRMT1TSHRKDM4E | |
| SCHEMBL17746937 | 0.95 | KDM4E (0.49) | EPHX2ADRA1APRMT1TSHRKDM4E | |
| SCHEMBL20556419 | 0.92 | EPHX2 (0.51) | EPHX2ADRA1APRMT1L3MBTL1KDM4E | |
| SCHEMBL540944 | 0.86 | CASP2 (0.59) | EPHX2L3MBTL1GAACASP2 | |
| SCHEMBL6535307 | 0.86 | TDP1 (0.61) | EPHX2ADRA1APRMT1KDM4EHDAC3 | |
| SCHEMBL23616304 | 0.86 | TDP1 (0.61) | EPHX2ADRA1APRMT1KDM4EHDAC3 | |
| SCHEMBL17751908 | 0.86 | CASP2 (0.59) | EPHX2L3MBTL1GAACASP2 | |
| SCHEMBL3288412 | 0.86 | TDP1 (0.61) | EPHX2ADRA1APRMT1KDM4EHDAC3 | |
| SCHEMBL12997717 | 0.86 | MEN1 (0.42) | EPHX2ADRA1APRMT1TSHRKDM4E | |
| SCHEMBL30111127 | 0.85 | EPHX2 (0.49) | EPHX2TSHRL3MBTL1HDAC8TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218392-B1 | MACROCYCLIC PEPTIDES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2020-07-29 | — | — | EP | disclosed |