Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 0.81 |
| ▸ | CCNE2 | O96020 | 8/20 | 0.81 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.81 |
| ▸ | CDK9 | P50750 | 11/20 | 0.77 |
| ▸ | CDK7 | P50613 | 4/20 | 0.77 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.77 |
| ▸ | CCNH | P51946 | 3/20 | 0.77 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.77 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.77 |
| ▸ | CDK1 | P06493 | 3/20 | 0.74 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.74 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.74 |
| ▸ | CDK4 | P11802 | 2/20 | 0.74 |
| ▸ | CCND1 | P24385 | 2/20 | 0.74 |
| ▸ | CCND2 | P30279 | 2/20 | 0.74 |
| ▸ | CCND3 | P30281 | 2/20 | 0.74 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.74 |
| ▸ | CIT | O14578 | 1/20 | 0.74 |
| ▸ | CASK | O14936 | 1/20 | 0.74 |
| ▸ | AURKA | O14965 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20905302 | 0.90 | CDK2 (1.00) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL22272120 | 0.89 | CDK2 (0.72) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL18613589 | 0.89 | CDK2 (0.84) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL24528750 | 0.89 | CDK2 (0.84) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL4994410 | 0.88 | CDK2 (0.83) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL24758393 | 0.88 | CDK2 (0.83) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL4928924 | 0.87 | CDK2 (0.81) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL17141895 | 0.87 | CDK2 (1.00) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL14067131 | 0.87 | CDK2 (0.82) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL4929170 | 0.86 | CDK2 (1.00) | CDK2CCNE2CCNE1CDK9CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3805218-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2021-04-14 | — | — | EP | disclosed |
| EP-3129371-B1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS INC (US) | 2020-07-29 | — | — | EP | disclosed |