Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 0.58 |
| ▸ | CCNE2 | O96020 | 8/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.58 |
| ▸ | CDK9 | P50750 | 10/20 | 0.55 |
| ▸ | CDK7 | P50613 | 4/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.55 |
| ▸ | CCNH | P51946 | 3/20 | 0.55 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17141875 | 0.94 | CDK2 (0.67) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL23220923 | 0.92 | CDK2 (0.61) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL17141904 | 0.86 | CDK2 (0.69) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL17141863 | 0.85 | CDK2 (0.70) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL22272122 | 0.84 | CDK2 (0.69) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL6184407 | 0.84 | CDK2 (0.70) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL17141909 | 0.83 | CDK2 (0.78) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL4215831 | 0.81 | CDK2 (0.79) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL17148373 | 0.80 | GLS (0.42) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL17148368 | 0.78 | CDK2 (0.76) | CDK2CCNE2CCNE1CDK9CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3129371-B1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS INC (US) | 2020-07-29 | — | — | EP | disclosed |