Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 9/20 | 0.58 |
| ▸ | QPCT | Q16769 | 5/20 | 0.48 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.48 |
| ▸ | AOC2 | O75106 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18609692 | 0.91 | MAP3K8 (0.49) | MAP3K8QPCTQPCTLAOC2PRKCI | |
| SCHEMBL7021141 | 0.82 | QPCT (0.66) | MAP3K8QPCTQPCTLAOC2PRKCI | |
| SCHEMBL38665709 | 0.82 | QPCT (0.66) | MAP3K8QPCTQPCTLAOC2PRKCI | |
| SCHEMBL18609345 | 0.77 | FGFR1 (0.56) | CYP1A2POLBCYP3A4CYP2D6MAPT | |
| SCHEMBL18584429 | 0.75 | PTGS2 (0.57) | CYP1A2POLBCYP3A4CYP2D6MAPT | |
| SCHEMBL18584473 | 0.75 | ATM (0.56) | CYP1A2POLBCYP3A4CYP2D6MAPT | |
| SCHEMBL18584395 | 0.75 | FGFR1 (0.48) | HTTPIK3CA | |
| SCHEMBL18584369 | 0.74 | CYP1A2 (0.45) | CYP1A2POLBCYP3A4CYP2D6MAPT | |
| SCHEMBL18584365 | 0.74 | KDR (0.61) | CYP1A2MAPTHTTPIK3CA | |
| SCHEMBL18609178 | 0.74 | DYRK1A (0.65) | QPCTPRKCICYP1A2POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10730842-B2 | Small molecule inhibitors of DYRK1A and uses thereof | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2020-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10730842-B2 | Small molecule inhibitors of DYRK1A and uses thereof | DYRK1A, DYRK2, DYRK1B | MAP3K8 33/4885QPCT 3627/4885QPCTL 3916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.