Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.55 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.46 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.46 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19781279 | 0.90 | KDR (0.68) | KDRGSK3BHTTALDH1A1HPGD | |
| SCHEMBL18609689 | 0.88 | KDR (0.57) | KDRGSK3BHTTALDH1A1HPGD | |
| SCHEMBL18609552 | 0.85 | KDR (0.74) | KDRGSK3BHTTALDH1A1HPGD | |
| SCHEMBL19781516 | 0.84 | GSK3B (0.61) | KDRGSK3BHTTALDH1A1HPGD | |
| SCHEMBL18584365 | 0.84 | KDR (0.61) | KDRGSK3BHTTALDH1A1HPGD | |
| SCHEMBL21449916 | 0.82 | PTGS2 (0.61) | KDRGSK3BHTTALDH1A1HPGD | |
| SCHEMBL19781594 | 0.81 | ATM (0.58) | KDRGSK3BHTTALDH1A1HPGD | |
| SCHEMBL19781278 | 0.81 | KDR (0.58) | KDRGSK3BHTTALDH1A1HPGD | |
| SCHEMBL19781592 | 0.81 | HTT (0.67) | KDRGSK3BHTTALDH1A1HPGD | |
| SCHEMBL21449915 | 0.81 | ATM (0.57) | KDRGSK3BHTTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10730842-B2 | Small molecule inhibitors of DYRK1A and uses thereof | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2020-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10730842-B2 | Small molecule inhibitors of DYRK1A and uses thereof | DYRK1A, DYRK2, DYRK1B | KDR 3000/4885GSK3B 739/4885HTT 1940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.