SCHEMBL2227367

SCHEMBL2227367

C/C(=N\c1ccccc1C(F)(F)F)c1cccc(/C(C)=N/c2ccccc2C(F)(F)F)n1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 2/20 0.47
NOS1 P29475 2/20 0.47
NOS2 P35228 2/20 0.47
GRIN2D O15399 1/20 0.44
GRIN3B O60391 1/20 0.44
GRIN1 Q05586 1/20 0.44
GRIN2A Q12879 1/20 0.44
GRIN2B Q13224 1/20 0.44
GRIN2C Q14957 1/20 0.44
GRIN3A Q8TCU5 1/20 0.44
SIGMAR1 Q99720 1/20 0.44
RAC1 P63000 1/20 0.43
PAK1 Q13153 1/20 0.43
KMT2A Q03164 3/20 0.40
MEN1 O00255 2/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
TNF P01375 1/20 0.36
CXCL8 P10145 1/20 0.36
PAX8 Q06710 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2227370 1.00 NOS3 (0.47) NOS3NOS1NOS2GRIN2DGRIN3B
Hydrochloric Acid SCHEMBL14632786 0.97 NOS3 (0.44) NOS3NOS1NOS2GRIN2DGRIN3B
Hydrochloric Acid SCHEMBL14632785 0.97 NOS3 (0.47) NOS3NOS1NOS2GRIN2DGRIN3B
SCHEMBL24404238 0.93 NOS3 (0.42) NOS3NOS1NOS2GRIN2DGRIN3B
SCHEMBL21113676 0.93 NOS3 (0.42) NOS3NOS1NOS2GRIN2DGRIN3B
SCHEMBL4890079 0.87 RAC1 (0.45) NOS3NOS1NOS2GRIN2DGRIN3B
SCHEMBL4890075 0.87 RAC1 (0.45) NOS3NOS1NOS2GRIN2DGRIN3B
SCHEMBL7261951 0.86 KDM4E (0.53) NOS3NOS1NOS2GRIN2DGRIN3B
SCHEMBL6227985 0.86 KDM4E (0.53) NOS3NOS1NOS2GRIN2DGRIN3B
SCHEMBL5354758 0.85 GRIN2D (0.45) NOS3NOS1NOS2GRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3135697-B1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST THEREOF CHINA PETROLEUM & CHEM CORP (CN) 2019-08-14 EP claimed
US-10208145-B2 Catalyst component for olefin polymerization, and catalyst containing the same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2019-02-19 US claimed
EP-3135697-A1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST THEREOF China Petroleum & Chemical Corporation (CN) 2017-03-01 EP claimed
EP-3135697-B1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST THEREOF CHINA PETROLEUM & CHEM CORP (CN) 2019-08-14 EP disclosed
US-10208145-B2 Catalyst component for olefin polymerization, and catalyst containing the same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2019-02-19 US disclosed
EP-3135697-A1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST THEREOF China Petroleum & Chemical Corporation (CN) 2017-03-01 EP disclosed
WO-2011089000-A1 PROCESS FOR THE PREPARATION OF ETHYLENE COPOLYMER COMPOSITIONS IN THE PRESENCE OF AN OLIGOMERIZATION CATALYST BASELL POLYOLEFINE GMBH (DE) 2011-07-28 WO disclosed
US-20080021180-A1 CHROMIUM CATALYSTS ACTIVE IN OLEFIN POLYMERIZATION REPSOL QUIMICA, S.A. 2008-01-24 US disclosed
EP-1325924-A1 Chromium catalysts active in olefin polymerisation REPSOL QUIMICA S.A. (ES) 2003-07-09 EP disclosed
EP-1325925-A1 Chromium catalysts active in olefin polymerization REPSOL QUIMICA S.A. (ES) 2003-07-09 EP disclosed