Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | POLR1A | O95602 | 5/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | USP7 | Q93009 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2229239 | 1.00 | MEN1 (0.57) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL2227633 | 0.78 | MAPT (0.89) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL2229536 | 0.78 | MAPT (0.89) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL13822374 | 0.78 | MAPT (0.89) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL2226783 | 0.77 | DRD4 (0.50) | USP7 | |
| SCHEMBL2227659 | 0.75 | ACHE (0.49) | ALDH1A1MAPTGAAGFERSMN1; SMN2 | |
| SCHEMBL2219175 | 0.71 | KMT2A (1.00) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL28598516 | 0.70 | NPSR1 (0.56) | MEN1KMT2APOLR1AKCNH2NPSR1 | |
| SCHEMBL13164063 | 0.69 | NPSR1 (0.58) | MEN1KMT2APOLR1ANPSR1 | |
| SCHEMBL15321974 | 0.69 | TP53 (0.64) | MEN1KMT2AALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523938-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | Hybrigenics S.A. (FR) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086178-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | HYBRIGENICS SA (FR) | 2011-07-21 | — | — | WO | disclosed |