SCHEMBL2227418

SCHEMBL2227418

N=NOCCO

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1669826 0.81
SCHEMBL15850361 0.67
SCHEMBL1828683 0.67
Hydrogen Sulfide SCHEMBL27615479 0.65
SCHEMBL11225973 0.65
SCHEMBL28987305 0.63
SCHEMBL2059055 0.63
SCHEMBL15358714 0.63
SCHEMBL15080984 0.63
SCHEMBL1628847 0.63

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9913912-B2 Carrier-linked prostanoid prodrugs ASCENDIS PHARMA A/S (DE) 2018-03-13 US disclosed
EP-2525830-B1 DIPEPTIDE-BASED PRODRUG LINKERS FOR ALIPHATIC AMINE-CONTAINING DRUGS ASCENDIS PHARMA AS (DK) 2016-05-11 EP disclosed
EP-2988783-A1 HYDROGEL-LINKED PRODRUGS RELEASING MODIFIED DRUGS Ascendis Pharma A/S (DK) 2016-03-02 EP disclosed
US-20150306239-A1 Carrier-Linked Prostanoid Prodrugs ASCENDIS PHARMA A/S (DK) 2015-10-29 US disclosed
WO-2014173759-A1 HYDROGEL-LINKED PRODRUGS RELEASING MODIFIED DRUGS ASCENDIS PHARMA A/S (DK) 2014-10-30 WO disclosed
EP-2741738-A1 SUSTAINED RELEASE COMPOSITION OF PROSTACYCLIN Ascendis Pharma A/S (DK) 2014-06-18 EP disclosed
EP-2741781-A1 CARRIER-LINKED TREPROSTINIL PRODRUGS Ascendis Pharma A/S (DK) 2014-06-18 EP disclosed
EP-2741744-A1 CARRIER-LINKED PRODRUGS HAVING REVERSIBLE CARBOXYLIC ESTER LINKAGES Ascendis Pharma A/S (DK) 2014-06-18 EP disclosed
WO-2013024053-A1 CARRIER-LINKED PRODRUGS HAVING REVERSIBLE CARBOXYLIC ESTER LINKAGES ASCENDIS PHARMA A/S (DK) 2013-02-21 WO disclosed
WO-2013024052-A1 CARRIER-LINKED TREPROSTINIL PRODRUGS ASCENDIS PHARMA A/S (DK) 2013-02-21 WO disclosed
WO-2013024051-A1 SUSTAINED RELEASE COMPOSITION OF PROSTACYCLIN ASCENDIS PHARMA A/S (DK) 2013-02-21 WO disclosed
WO-2011089216-A1 DIPEPTIDE-BASED PRODRUG LINKERS FOR ALIPHATIC AMINE-CONTAINING DRUGS ASCENDIS PHARMA AS (DK) 2011-07-28 WO disclosed
WO-2011089214-A1 CARRIER-LINKED CARBAMATE PRODRUG LINKERS ASCENDIS PHARMA AS (DK) 2011-07-28 WO disclosed
WO-2011089215-A1 DIPEPTIDE-BASED PRODRUG LINKERS FOR AROMATIC AMINE-CONTAINING DRUGS ASCENDIS PHARMA AS (DK) 2011-07-28 WO disclosed