SCHEMBL22276249

SCHEMBL22276249

O=C(O)c1cccc2ccn(Cc3ccc(-c4ccccc4)nc3)c12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 5/20 0.45
CYP11B2 P19099 5/20 0.45
LDHA P00338 2/20 0.42
FEN1 P39748 1/20 0.41
DHODH Q02127 1/20 0.41
KMT2A Q03164 1/20 0.41
CYP2C8 P10632 1/20 0.40
CYP2C9 P11712 1/20 0.40
HCAR2 Q8TDS4 1/20 0.40
PTGER4 P35408 3/20 0.40
PTGDR Q13258 3/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
TBXA2R P21731 1/20 0.39
PTGER1 P34995 1/20 0.39
PTGFR P43088 1/20 0.39
PTGER3 P43115 1/20 0.39
PTGER2 P43116 1/20 0.39
AGTR1 P30556 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22276250 0.91 PARP1 (0.46) CYP11B1CYP11B2LDHAFEN1KMT2A
SCHEMBL22276248 0.88 CYP11B1 (0.41) CYP11B1CYP11B2KMT2APTGER4PTGDR
SCHEMBL12584205 0.85 HCAR2 (0.48) DHODHHCAR2PTGER4PTGDRTBXA2R
SCHEMBL989493 0.84 CHRM1 (0.50) DHODHPTGER4PTGDRTBXA2RPTGER1
SCHEMBL28493533 0.84 PTGER4 (0.42) CYP11B1CYP11B2FEN1PTGER4PTGDR
SCHEMBL13390817 0.83 PTGER4 (0.43) KMT2APTGER4PTGDRSMN1; SMN2TBXA2R
SCHEMBL12584088 0.83 KMT2A (0.57) KMT2APTGER4PTGDRTBXA2RPTGER1
SCHEMBL27837553 0.81 PTGER4 (0.68) PTGER4PTGDR
SCHEMBL988187 0.81 PTGER4 (0.68) PTGER4PTGDR
SCHEMBL7652408 0.81 NOTUM (0.56) PTGER4PTGDRTBXA2RPTGER1PTGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3889134-A1 COMPOUND FOR INHIBITING PGE2/EP4 SIGNALING TRANSDUCTION INHIBITING, PREPARATION METHOD THEREFOR, AND MEDICAL USES THEREOF Keythera (Suzhou) Pharmaceuticals Co. Ltd. (CN) 2021-10-06 EP disclosed
WO-2020151566-A1 COMPOUND FOR INHIBITING PGE2/EP4 SIGNALING TRANSDUCTION INHIBITING, PREPARATION METHOD THEREFOR, AND MEDICAL USES THEREOF 凯复制药有限公司 2020-07-30 WO disclosed