Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 3/20 | 0.52 |
| ▸ | PTGER4 | P35408 | 6/20 | 0.51 |
| ▸ | PTGDR | Q13258 | 5/20 | 0.51 |
| ▸ | FABP4 | P15090 | 4/20 | 0.49 |
| ▸ | SNCA | P37840 | 2/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.47 |
| ▸ | PTGFR | P43088 | 1/20 | 0.47 |
| ▸ | FABP3 | P05413 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989493 | 0.91 | CHRM1 (0.50) | NOTUMAPPPTGER4PTGDRFABP4 | |
| SCHEMBL987890 | 0.90 | PTGER4 (0.51) | NOTUMAPPPTGER4PTGDRFABP4 | |
| SCHEMBL13802480 | 0.89 | PTGER4 (0.64) | NOTUMPTGER4PTGDRPTGER2ADRA1D | |
| SCHEMBL12584024 | 0.89 | PTGER4 (0.48) | NOTUMAPPPTGER4PTGDRFABP4 | |
| SCHEMBL12900317 | 0.88 | NOTUM (0.51) | NOTUMAPPPTGER4PTGDRFABP4 | |
| SCHEMBL12900314 | 0.88 | FABP4 (0.50) | NOTUMAPPPTGER4PTGDRFABP4 | |
| SCHEMBL988161 | 0.86 | PTGER4 (0.50) | NOTUMAPPPTGER4PTGDRFABP4 | |
| SCHEMBL22393055 | 0.85 | APP (0.48) | NOTUMAPPPTGER4PTGDRSNCA | |
| SCHEMBL20542260 | 0.85 | PTGER4 (0.54) | NOTUMAPPPTGER4PTGDRFABP4 | |
| SCHEMBL20541945 | 0.85 | PTGER4 (0.47) | NOTUMAPPPTGER4PTGDRFABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2460787-A1 | Amide compounds and their use as PGE2 antagonists. | Astellas Pharma Inc. (JP) | 2012-06-06 | — | — | EP | disclosed |
| US-8158671-B2 | Indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists | MERCK CANADA INC. (CA) | 2012-04-17 | — | — | US | disclosed |
| US-20110028463-A1 | AMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2011-02-03 | — | — | US | disclosed |
| US-20090318518-A1 | INDOLE AND INDOLINE CYCLOPROPYL AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | MERCK CANADA INC. (CA) | 2009-12-24 | — | — | US | disclosed |
| US-6489354-B1 | IN PARTICULAR, THESE COMPOUNDS ARE USEFUL AS MODULATORS OF THE CHEMOKINE RECEPTORS CCR-3 AND/OR CCR-5 USEFUL IN THE TREATMENT AND PREVENTION OF ATOPIC CONDITIONS INCLUDING ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, AND ASTHMA | MERCK & CO., INC. | 2002-12-03 | — | — | US | disclosed |
| US-6372764-B1 | ANTIINFLAMMATORY AGENTS AND AIDS TREATMENT | MERCK & CO., INC. | 2002-04-16 | — | — | US | disclosed |
| WO-2000051609-A1 | 3-ALKYL SUBSTITUTED PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318518-A1 | INDOLE AND INDOLINE CYCLOPROPYL AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | PTGER4, PTGER1, PTGER3 | NOTUM 2678/4885APP 2604/4885PTGER4 1/4885 |
| US-20110028463-A1 | AMIDE COMPOUNDS | PTGER4, PTGER1, PTGER2 | NOTUM 1532/4885APP 4262/4885PTGER4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.