Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 10/20 | 0.52 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.42 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 2/20 | 0.41 |
| ▸ | IL1B | P01584 | 2/20 | 0.41 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24458964 | 0.88 | HDAC1 (0.48) | CRBNDDB1BRD4HDAC3HDAC1 | |
| SCHEMBL24391012 | 0.84 | CRBN (0.47) | CRBNDDB1MAP1LC3BBRD4HDAC3 | |
| SCHEMBL30241739 | 0.83 | CRBN (0.52) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL26148008 | 0.83 | CRBN (0.52) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL18493738 | 0.82 | CRBN (0.66) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL21106304 | 0.81 | CRBN (0.40) | CRBNDDB1IKZF3MAP1LC3BALDH1A1 | |
| SCHEMBL24937918 | 0.80 | STAT3 (0.51) | CRBNDDB1BRD4GSK3BHDAC3 | |
| SCHEMBL22276654 | 0.80 | CRBN (0.79) | CRBNDDB1IKZF3MAP1LC3BALDH1A1 | |
| SCHEMBL18438844 | 0.80 | CRBN (0.79) | CRBNDDB1IKZF3MAP1LC3BALDH1A1 | |
| SCHEMBL17873788 | 0.80 | CRBN (0.79) | CRBNDDB1IKZF3MAP1LC3BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020152067-A1 | HETEROCYCLIC DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-07-30 | — | — | WO | disclosed |