Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | USP7 | Q93009 | 1/20 | 0.48 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2228012 | 1.00 | MAPT (0.52) | MAPTTP53ALDH1A1MAPK1KMT2A | |
| SCHEMBL2227598 | 0.90 | MAPT (0.62) | MAPTTP53ALDH1A1MAPK1KMT2A | |
| SCHEMBL2220853 | 0.90 | MAPT (0.62) | MAPTTP53ALDH1A1MAPK1KMT2A | |
| SCHEMBL2230042 | 0.90 | MAPT (0.62) | MAPTTP53ALDH1A1MAPK1KMT2A | |
| SCHEMBL2226684 | 0.87 | MAPT (0.64) | MAPTTP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL15988228 | 0.77 | ALDH1A1 (0.49) | MAPTTP53ALDH1A1MAPK1KMT2A | |
| SCHEMBL2228666 | 0.75 | KMT2A (0.68) | MAPTTP53ALDH1A1MAPK1KMT2A | |
| SCHEMBL14651035 | 0.73 | MAPT (0.57) | MAPTTP53ALDH1A1MAPK1KMT2A | |
| SCHEMBL2217604 | 0.73 | SMN1; SMN2 (0.75) | MAPTTP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL13822539 | 0.71 | MAPT (0.65) | MAPTTP53ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523938-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | Hybrigenics S.A. (FR) | 2012-11-21 | — | — | EP | claimed |
| WO-2011086178-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | HYBRIGENICS SA (FR) | 2011-07-21 | — | — | WO | claimed |
| EP-2523938-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | Hybrigenics S.A. (FR) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086178-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | HYBRIGENICS SA (FR) | 2011-07-21 | — | — | WO | disclosed |