Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 6/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14153766 | 0.74 | HTT (0.53) | S1PR1ALDH1A1NPSR1KMT2ATP53 | |
| SCHEMBL22280304 | 0.72 | CNR2 (0.38) | HDAC6HDAC1JAK2JAK1TYK2 | |
| SCHEMBL9963719 | 0.72 | S1PR1 (0.60) | S1PR1ALDH1A1NPSR1TP53SMN1; SMN2 | |
| SCHEMBL14062303 | 0.71 | TSHR (0.42) | S1PR1ALDH1A1NPSR1KMT2ATP53 | |
| SCHEMBL30796235 | 0.71 | TSHR (0.42) | S1PR1ALDH1A1NPSR1KMT2ATP53 | |
| SCHEMBL22280448 | 0.70 | NR1H4 (0.47) | AURKACNR2 | |
| SCHEMBL22280558 | 0.70 | NR1H4 (0.47) | AURKACNR2 | |
| SCHEMBL14153217 | 0.70 | S1PR1 (0.49) | HDAC4HDAC6HDAC1S1PR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL22266080 | 0.69 | NR1H4 (0.47) | AURKACNR2 | |
| Hydrochloric Acid SCHEMBL22266083 | 0.69 | NR1H4 (0.47) | AURKACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |