Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | JAK1 | P23458 | 4/20 | 0.38 |
| ▸ | TYK2 | P29597 | 4/20 | 0.38 |
| ▸ | JAK3 | P52333 | 4/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | TTK | P33981 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TEK | Q02763 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280302 | 0.72 | HDAC4 (0.40) | CNR2JAK2JAK1TYK2JAK3 | |
| SCHEMBL22280558 | 0.70 | NR1H4 (0.47) | CNR2CCNA2CDK2TTKAURKA | |
| SCHEMBL22280448 | 0.70 | NR1H4 (0.47) | CNR2CCNA2CDK2TTKAURKA | |
| Hydrochloric Acid SCHEMBL22266083 | 0.69 | NR1H4 (0.47) | CNR2CCNA2CDK2TTKAURKA | |
| SCHEMBL11566527 | 0.69 | HCAR3 (0.65) | JAK2JAK1TYK2JAK3AURKA | |
| SCHEMBL22280478 | 0.69 | KDM4E (0.42) | TYK2MAPTRAB9AKMT2A | |
| SCHEMBL22266118 | 0.67 | FLT3 (0.54) | IGF1RJAK2JAK1TYK2JAK3 | |
| SCHEMBL22280477 | 0.67 | CNR2 (0.49) | CNR2IGF1RJAK2JAK1TYK2 | |
| SCHEMBL22265582 | 0.66 | F10 (0.49) | JAK2JAK1TYK2JAK3AURKA | |
| SCHEMBL22265584 | 0.66 | F10 (0.49) | JAK2JAK1TYK2JAK3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |