Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22265891 | 0.86 | SPHK2 (0.43) | NPC1RAB9ATLR9TLR8TLR7 | |
| SCHEMBL22265894 | 0.86 | SPHK2 (0.43) | NPC1RAB9ATLR9TLR8TLR7 | |
| Hydrochloric Acid SCHEMBL29523015 | 0.85 | SPHK2 (0.42) | NPC1RAB9ATLR9TLR8TLR7 | |
| SCHEMBL22280267 | 0.85 | NR1H4 (0.49) | NPC1RAB9ATLR9TLR8TLR7 | |
| SCHEMBL22280324 | 0.84 | NPC1 (0.66) | NPC1RAB9ATLR9TLR8TLR7 | |
| SCHEMBL22280323 | 0.84 | NPC1 (0.66) | NPC1RAB9ATLR9TLR8TLR7 | |
| Hydrochloric Acid SCHEMBL22265304 | 0.83 | SPHK2 (0.47) | TLR9TLR8TLR7 | |
| Hydrochloric Acid SCHEMBL22265303 | 0.83 | SPHK2 (0.47) | TLR9TLR8TLR7 | |
| SCHEMBL22280331 | 0.82 | NR1H4 (0.49) | NPC1RAB9ATLR9TLR8TLR7 | |
| SCHEMBL22280449 | 0.82 | NR1H4 (0.44) | TLR9TLR8TLR7NR1H4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |