Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PLAT | P00750 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280324 | 1.00 | NPC1 (0.66) | NPC1RAB9ANR1H4LMNAHTT | |
| SCHEMBL22280325 | 0.92 | RAB9A (0.71) | NPC1RAB9ANR1H4LMNAHTT | |
| SCHEMBL22280269 | 0.92 | RAB9A (0.71) | NPC1RAB9ANR1H4LMNAHTT | |
| SCHEMBL4416033 | 0.92 | NPC1 (0.74) | NPC1RAB9ANR1H4LMNAHTT | |
| Hydrochloric Acid SCHEMBL193440 | 0.91 | RAB9A (0.69) | NPC1RAB9ANR1H4LMNAHTT | |
| Hydrochloric Acid SCHEMBL193439 | 0.91 | RAB9A (0.69) | NPC1RAB9ANR1H4LMNAHTT | |
| Hydrochloric Acid SCHEMBL7551864 | 0.90 | NPC1 (0.72) | NPC1RAB9ANR1H4LMNAHTT | |
| SCHEMBL26887363 | 0.89 | NR1H4 (0.66) | NPC1RAB9ANR1H4LMNAHTT | |
| SCHEMBL22280438 | 0.88 | NPC1 (0.68) | NPC1RAB9ANR1H4LMNAHTT | |
| SCHEMBL22265529 | 0.84 | NR1H4 (0.51) | NPC1RAB9ANR1H4LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |